Alternative titles; symbolsZINC FINGER PROTEIN 123; ZNF123HGNC Approved Gene Symbol: ZNF123PCytogenetic location: 11q23.1-q23.2 Genomic coordinates (GRCh38):...
Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF123P
Cytogenetic location: 11q23.1-q23.2 Genomic coordinates (GRCh38): 11:110,600,000-114,600,000
▼ Cloning and Expression
Saleh et al. (1992) isolated, characterized, and mapped zinc finger-encoding genes specific to human chromosome 11q to investigate their possible association in a molecular pathogenesis of diseases mapping to that area of the genome. They screened an arrayed chromosome 11q cosmid library using a degenerate oligonucleotide corresponding to the histidine/cysteine link consensus sequence of the Drosophila Kruppel zinc finger gene. Six putative zinc finger genes were isolated; 3 of these--ZNF123, ZNF125 (194632), and ZNF126 (194633)--were analyzed and shown to contain tandemly repeated zinc finger motifs of the C2-H2 class. All 3 novel genes were found to be expressed in normal adult human tissues, although the tissue-specific pattern expression differed markedly. The ZNF123 gene was found to be expressed as a 3.5-kb transcript exclusively in human liver.
Saleh et al. (1992) regionally mapped the ZNF123, ZNF125, and ZNF126 genes to chromosome 11 using fluorescence in situ suppression hybridization (FISSH) as described by Selleri et al. (1991). The clone referred to as HZF-2, relating to the gene symbolized ZNF126, mapped to 11q13.3-q13.4; the clones HZF-1 and HZF-3, identified with genes ZNF123 and ZNF125, respectively, mapped to 11q23.1-q23.2.