MITOCHONDRIAL RIBOSOMAL PROTEIN L41; MRPL41

Alternative titles; symbols

• MRPL27

HGNC Approved Gene Symbol: MRPL41

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,551,878-137,552,554 (from NCBI)

▼ Description
Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation. MRPL41 is 1 of more than 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome (Kenmochi et al., 2001).

▼ Cloning and Expression
By searching databases for homologs of rat Mrpl27, Goldschmidt-Reisin et al. (1998) identified mouse and human MRPL41, which they called MRPL27. The deduced 136-amino acid human MRPL41 protein contains a 13-amino acid N-terminal mitochondrial import signal.

▼ Mapping
By radiation hybrid analysis and analysis of an integrated BAC-STS map, Kenmochi et al. (2001) mapped the MRPL41 gene to chromosome 9q34.3.