MITOCHONDRIAL RIBOSOMAL PROTEIN L14; MRPL14

Alternative titles; symbols

• MRPL32

HGNC Approved Gene Symbol: MRPL14

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,113,450-44,127,451 (from NCBI)

▼ Description
Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation. MRPL14 is 1 of more than 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome (Kenmochi et al., 2001).

▼ Cloning and Expression
By searching databases for homologs of rat Mrpl32, Goldschmidt-Reisin et al. (1998) identified mouse and human MRPL14, which they called MRPL32. The deduced human protein contains a 64-amino acid N-terminal mitochondrial import signal.

▼ Mapping
By radiation hybrid analysis and analysis of an integrated BAC-STS map, Kenmochi et al. (2001) mapped the MRPL14 gene to chromosome 6p21.3.