Alternative titles; symbolsCD112 RECEPTOR; CD112RCHROMOSOME 7 OPEN READING FROME 15; C7ORF15HGNC Approved Gene Symbol: PVRIGCytogenetic location: 7q22.1 Geno...
Alternative titles; symbols
HGNC Approved Gene Symbol: PVRIG
Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,218,624-100,221,489 (from NCBI)
PVRIG, also termed CD112R, is a coinhibitory receptor on T cells. CD112 (PVRL2; 600798), expressed on antigen-presenting cells, is a high-affinity ligand for CD112R (Zhu et al., 2016).
▼ Cloning and Expression
By comparative genomic and sequence analysis, Wilson et al. (2006) identified the PVRIG gene, arising from duplication together with STAG3 (608489), on chromosome 7.
By searching for genes encoding a single IgV extracellular domain and preferentially expressed on T cells, Zhu et al. (2016) identified PVRIG, which they termed CD112R to reflect its strong interaction with CD112. The predicted 173-amino acid single-transmembrane protein has a long intracellular domain with 2 tyrosine residues, 1 of which is located in an ITIM (immunoreceptor tyrosine-based inhibitory motif)-like motif that may serve a dock for phosphatases. Database analysis, with RT-PCR confirmation, for mRNA expression indicated preferential expression in lymphocytes, particularly T and NK cells, but not on dendritic cells (DCs). Western blot and flow cytometric analyses showed monomeric expression of a 36-kD protein predominantly in lymphocytes.
▼ Gene Function
Zhu et al. (2016) showed that CD112R recruits tyrosine phosphatases for signal transduction and could act as a coinhibitory receptor that suppresses T cell receptor (TCR) signaling. They also demonstrated that CD112, expressed on tumor cells and DCs, is a ligand for CD112R. Zhu et al. (2016) concluded that CD112R is a coinhibitory receptor for CD112.
Wilson et al. (2006) mapped the PVRIG gene to chromosome 7q22.1, proximal to PILRB (605342).