MAS-RELATED G PROTEIN-COUPLED RECEPTOR FAMILY, MEMBER D; MRGPRD

Alternative titles; symbols

• MRGD

HGNC Approved Gene Symbol: MRGPRD

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:68,980,020-68,980,985 (from NCBI)

▼ Cloning and Expression
Dong et al. (2001) identified, in the mouse and human genomes, a family of G protein-coupled receptors (GPCRs) related to the MAS1 oncogene (165180), including MRGD. Several pseudogenes were also identified. The predicted MRG proteins contain transmembrane, extracellular, and cytoplasmic domains. A subset of MRGs was expressed in specific subpopulations of sensory neurons that detect painful stimuli. The expression patterns of these genes thus revealed an unexpected degree of molecular diversity among nociceptive neurons. Some MRGs could be specifically activated in heterologous cells by RFamide neuropeptides such as NPFF and NPAF (see 604643), which are analgesic in vivo. The authors concluded that MRGs may regulate nociceptor function and/or development, including the sensation or modulation of pain.

▼ Mapping
By genomic sequence analysis, Dong et al. (2001) mapped the MRGD gene to chromosome 11.