Alternative titles; symbolsHISTONE GENE CLUSTER 1, H4LHIST1 CLUSTER, H4LH4 HISTONE FAMILY, MEMBER K; H4FKH4/KHGNC Approved Gene Symbol: H4C13Cytogenetic location...
Alternative titles; symbols
HGNC Approved Gene Symbol: H4C13
Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:27,873,147-27,873,533 (from NCBI)
For background information on histones, histone gene clusters, and the H4 histone family, see HIST1H4A (602822).
▼ Cloning and Expression
Albig et al. (1997) identified a gene, designated H4/k, encoding a member of the H4 class of histones.
By genomic sequence analysis, Marzluff et al. (2002) identified the human HIST1H4L gene. All H4 genes, including HIST1H4L, encode the same protein.
By analysis of a YAC contig from chromosome 6p22-p21.3, Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H4/k, located 2 Mb centromeric to the major histone gene cluster.
By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H4L.
▼ Gene Function
See HIST1H4A (602822) for functional information on H4 histones.