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HISTONE GENE CLUSTER 1, H4 HISTONE FAMILY, MEMBER L; HIST1H4L

HISTONE GENE CLUSTER 1, H4 HISTONE FAMILY, MEMBER L; HIST1H4L

Alternative titles; symbolsHISTONE GENE CLUSTER 1, H4LHIST1 CLUSTER, H4LH4 HISTONE FAMILY, MEMBER K; H4FKH4/KHGNC Approved Gene Symbol: H4C13Cytogenetic location...

Alternative titles; symbols

  • HISTONE GENE CLUSTER 1, H4L
  • HIST1 CLUSTER, H4L
  • H4 HISTONE FAMILY, MEMBER K; H4FK
  • H4/K

HGNC Approved Gene Symbol: H4C13

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:27,873,147-27,873,533 (from NCBI)

▼ TEXT
For background information on histones, histone gene clusters, and the H4 histone family, see HIST1H4A (602822).

▼ Cloning and Expression
Albig et al. (1997) identified a gene, designated H4/k, encoding a member of the H4 class of histones.

By genomic sequence analysis, Marzluff et al. (2002) identified the human HIST1H4L gene. All H4 genes, including HIST1H4L, encode the same protein.

▼ Mapping
By analysis of a YAC contig from chromosome 6p22-p21.3, Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H4/k, located 2 Mb centromeric to the major histone gene cluster.

By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H4L.

▼ Gene Function
See HIST1H4A (602822) for functional information on H4 histones.

Tags: 6p22.1