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  • 总部: 泰国曼谷市巴吞汪区仑披尼分区 普勒吉路齐隆巷5号.
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LATE CORNIFIED ENVELOPE 1C; LCE1C

LATE CORNIFIED ENVELOPE 1C; LCE1C

Alternative titles; symbolsLATE ENVELOPE PROTEIN 3; LEP3HGNC Approved Gene Symbol: LCE1CCytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,804,...

Alternative titles; symbols

  • LATE ENVELOPE PROTEIN 3; LEP3

HGNC Approved Gene Symbol: LCE1C

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,804,831-152,806,650 (from NCBI)

▼ TEXT
For background information on the LCE gene cluster, see 612603.

▼ Cloning and Expression
By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE1C, which they called LEP3.

Using real-time PCR, Jackson et al. (2005) detected high LCE1C expression in human fetal, arm, penal, and abdominal skin. Expression was much lower in vulva and was not detected in tongue and esophagus.

▼ Gene Function
Jackson et al. (2005) showed that expression of LCE1 genes, including LCE1C, was upregulated in cultured normal human keratinocytes by ultraviolet (UV) irradiation, but not by calcium. Induction of LCE1C could be detected 24 hours after UV irradiation and was very high 36 hours after UV irradiation.

▼ Gene Structure
Jackson et al. (2005) determined that the LCE1C gene contains 2 exons. Exon 1 is noncoding.

▼ Mapping
By genomic sequence analysis, Marshall et al. (2001) mapped the LCE1C gene within the LCE gene cluster on chromosome 1q21. Jackson et al. (2005) stated that the mouse Lce1c gene maps to a syntenic LCE gene cluster on chromosome 3F1.

Tags: 1q21.3