SHISA FAMILY, MEMBER 6; SHISA6

HGNC Approved Gene Symbol: SHISA6

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:11,241,212-11,564,062 (from NCBI)

▼ Cloning and Expression
Pei and Grishin (2012) reported that the deduced 551-amino acid human SHISA6 protein has a domain structure typical of SHISA proteins, including an N-terminal signal peptide, followed by a cysteine-rich domain, a transmembrane domain, and a C-terminal proline-rich region. SHISA6 belongs to a SHISA subfamily containing SHISA7 (617328), SHISA8 (617329), and SHISA9 (613346).

▼ Mapping
Hartz (2017) mapped the SHISA6 gene to chromosome 17p12 based on an alignment of the SHISA6 sequence (GenBank AK127379) with the genomic sequence (GRCh38).