Alternative titles; symbolsmiRNA99BHGNC Approved Gene Symbol: MIR99BCytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,692,611-51,692,680 (fr...
Alternative titles; symbols
HGNC Approved Gene Symbol: MIR99B
Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,692,611-51,692,680 (from NCBI)
Micro RNAs (miRNAs), such as MIR99B, are small noncoding RNAs that typically bind to the 3-prime UTR of a target mRNA and regulate its expression by degrading the mRNA or repressing its translation. MIR99B belongs to the MIR99 family of miRNAs, which also includes MIR99A (614509) and MIR100 (613186). Members of this family have the same seed sequence for interaction with target mRNAs (Sun et al., 2011).
▼ Gene Function
Sun et al. (2011) found that expression of MIR125B2 (610105) and all MIR99 family members was downregulated in the C4-2 human androgen-independent prostate cancer cell line compared with the parental LNCaP androgen-dependent cell line. All 4 miRNAs were also downregulated in human prostate tumor tissue compared with normal prostate. Transfection of C4-2 cells with MIR99A, MIR99B, or MIR100 inhibited cell growth and decreased expression of PSA (KLK3; 176820), a secreted protease and prostate cancer marker. PSA expression was downregulated indirectly, at least in part, by MIR99-mediated downregulation of SMARCA5 (603375) expression. Other direct targets of the MIR99 family included SMARCD1 (601735) and MTOR (FRAP1; 601231).
Hartz (2012) mapped the MIR99B gene to chromosome 19q13.41 based on an alignment of the mature MIR99B sequence (CACCCGUAGAACCGACCUUGCG) with the genomic sequence (GRCh37).