TAF6-LIKE RNA POLYMERASE II; TAF6L

Alternative titles; symbols

• PCAF-ASSOCIATED FACTOR 65 ALPHA; PAF65A
• PCAF-ASSOCIATED FACTOR, 65-KD

HGNC Approved Gene Symbol: TAF6L

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,771,395-62,787,341 (from NCBI)

▼ Cloning and Expression
Ogryzko et al. (1998) identified the human polypeptide PAF65A as a subunit of the PCAF complex (see 602303). PAF65A shows sequence similarity to human TAFII80 (602955). The predicted 622-amino acid protein contains a histone H4-like region (residues 12-86).

▼ Gene Function
Struhl and Moqtaderi (1998) reviewed the potential roles of the PCAF complex in transcription.

▼ Mapping
Hartz (2009) mapped the TAF6L gene to chromosome 11q12.3 based on an alignment of the TAF6L sequence (GenBank AF069735) with the genomic sequence (GRCh37).