[email protected] (受疫情影响,东南亚目前只开放曼谷诊所)
全周 (9AM - 5PM)

我们和你在一起

Extra info thumb
  • 总部: 泰国曼谷市巴吞汪区仑披尼分区 普勒吉路齐隆巷5号.
  • [email protected]
POLYCOMB GROUP RING FINGER PROTEIN 1; PCGF1

POLYCOMB GROUP RING FINGER PROTEIN 1; PCGF1

Alternative titles; symbolsMGC10882NERVOUS SYSTEM POLYCOMB 1; NSPC1LETHAL(3)73AH, DROSOPHILA, HOMOLOG OFHGNC Approved Gene Symbol: PCGF1Cytogenetic location: 2p1...

Alternative titles; symbols

  • MGC10882
  • NERVOUS SYSTEM POLYCOMB 1; NSPC1
  • LETHAL(3)73AH, DROSOPHILA, HOMOLOG OF

HGNC Approved Gene Symbol: PCGF1

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,505,042-74,507,694 (from NCBI)

▼ Description
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001).

▼ Cloning and Expression
By searching for cDNAs containing a RING finger motif, followed by screening a human testis and heart cDNA library, Nunes et al. (2001) cloned PCGF1, which they called NSPC1. The deduced 259-amino acid protein contains an N-terminal RING finger domain and shares 97.5% amino acid identity with mouse Nspc1, and 39% identity with both mammalian Pcgf2 and Bmi1 (164831). Northern blot analysis detected a 1.4-kb major transcript with highest expression in adult human colon, small intestine, prostate, and testis, and a 1.0-kb minor transcript, which lacks the RING finger domain, with low expression in small intestine, colon, and peripheral blood leukocytes. By in situ hybridization of mouse embryos, Nunes et al. (2001) demonstrated that Nspc1 is first expressed 10.5 days postcoitum (dpc) in the otic vesicle, the anterior limb bud of the dorsal root ganglia, and the genital tubercle. At 11.5 dpc, expression was observed in the dorsal root ganglia, dorsal epithelium of the neural tube, heart, and branchial arches. The authors detected Nspc1 expression in a subset of neural crest cell derivatives, which give rise to the peripheral nervous system. By 13.5 dpc, Nunes et al. (2001) detected widespread Nspc1 expression.

▼ Gene Structure
Nunes et al. (2001) determined that the PCGF1 gene contains 9 exons.

▼ Mapping
By radiation hybrid analysis, Nunes et al. (2001) mapped the PCGF1 gene to chromosome 2p13. The mouse Pcgf1 gene was mapped to a syntenic region on mouse chromosome 6.

▼ Gene Function
Using a bacterial 2-hybrid system, Junco et al. (2013) found that the C-terminal ubiquitin-like fold domains of PCGF1 and PCGF3 (617543) interacted with the C-terminal domains of BCOR (300485) and BCORL1 (300688).

Tags: 2p13.1