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PYGOPUS FAMILY PHD FINGER 2; PYGO2

PYGOPUS FAMILY PHD FINGER 2; PYGO2

Alternative titles; symbolsPYGOPUS, DROSOPHILA, HOMOLOG OF, 2HGNC Approved Gene Symbol: PYGO2Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154...

Alternative titles; symbols

PYGOPUS, DROSOPHILA, HOMOLOG OF, 2

HGNC Approved Gene Symbol: PYGO2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,957,025-154,961,781 (from NCBI)

▼ Cloning and Expression
WNT (see 602863) signaling controls many fundamental processes during animal development. WNT transduction is mediated by the association of beta-catenin (116806) with nuclear TCF (e.g., LEF1; 153245) DNA-binding factors. Kramps et al. (2002) identified 2 segment polarity genes in Drosophila, legless (Lgs), and pygopus (Pygo), and showed that their products are required for WNT signal transduction at the level of nuclear beta-catenin. Lgs encodes the homolog of human BCL9 (602597), and the authors provided genetic and molecular evidence that these proteins exert their function by physically linking Pygo to beta-catenin. Kramps et al. (2002) identified and isolated 2 human homologs of the Drosophila Pygo gene, PYGO1 (606902) and PYGO2. The PYGO1 and PYGO2 proteins, which contain 419 and 406 amino acids, respectively, possess a highly conserved PHD finger that interacts with homology domain-1 (HD1) of BCL9. The findings suggested that the recruitment of PYGO permits beta-catenin to transcriptionally activate WNT target genes and raised the possibility that a deregulation of these events may play a causal role in the development of B-cell malignancies.

▼ Mapping
The International Radiation Hybrid Mapping Consortium mapped the PYGO2 gene to chromosome 1 (sts-W05360).

Tags: 1q21.3