TBK1-BINDING PROTEIN 1; TBKBP1

Alternative titles; symbols

• PROSAPIP2
• KIAA0775

HGNC Approved Gene Symbol: TBKBP1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,694,062-47,712,062 (from NCBI)

▼ Description
TBKBP1 is an adaptor protein that binds to TBK1 (604834) and is part of the interaction network in the TNF (191160)/NFKB (see 164011) pathway (Bouwmeester et al., 2004).

▼ Cloning and Expression
By searching for sequences with the potential to encode large proteins expressed in brain, Nagase et al. (1998) identified a cDNA encoding KIAA0775. The predicted protein contains 615 amino acids. RT-PCR analysis detected ubiquitous expression, with highest levels in ovary, followed by testis, brain, heart, lung, smooth muscle, kidney, and liver.

▼ Mapping
The International Radiation Hybrid Mapping Consortium mapped the TBKBP1 gene to chromosome 17 (WI-14964).