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LACTATE DEHYDROGENASE C; LDHC

LACTATE DEHYDROGENASE C; LDHC

Alternative titles; symbolsLDH, TESTICULAR FORM; LDHXHGNC Approved Gene Symbol: LDHCCytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,412,297...

Alternative titles; symbols

  • LDH, TESTICULAR FORM; LDHX

HGNC Approved Gene Symbol: LDHC

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,412,297-18,452,062 (from NCBI)

▼ Cloning and Expression
Zinkham et al. (1964) found a distinctive LDH isozyme in mature testes of many species including man. It is polymorphic in the pigeon, and one can infer that a locus separate from LDHA (150000) and LDHB (150100) controls it. The same is almost certainly true in the human. This is a gene that functions only in one sex and only in one tissue.

Sakai et al. (1987) isolated and sequenced cDNA clones of LDHC from the mouse. Northern blot analysis of poly(A)-containing RNAs from mouse testes and liver indicated that the Ldhc gene was expressed in testes but not in liver. The nucleotide and amino acid sequences of mouse Ldhc showed 73 and 72% homology, respectively, with those of mouse Ldha. Southern blot analysis of genomic DNAs from mouse liver and human placenta indicated the presence of multiple LDH-C gene-related sequences. From the amino acid sequence deduced from cDNA, Millan et al. (1987) found that human LDHC is as different from rodent Ldhc (73% homology) as it is from human LDHA (76% homology) and porcine LDHB (68% homology).

▼ Mapping
Zinkham et al. (1969) found that the LDHB and LDHC loci are closely linked in pigeons. Edwards et al. (1987) used an LDHC cDNA to analyze genomic DNA from rodent/human somatic cell hybrids. These showed that LDHA and LDHC are syntenic on human chromosome 11. The assignment of LDHC was confirmed by Kao et al. (1988), who localized the gene to 11p15.5-p14.3 by use of somatic cell hybrids and in situ chromosome hybridization. Li et al. (1988) also assigned LDHC to chromosome 11 by hybridization of DNA from flow-sorted chromosomes. The close physical proximity of the LDHC and LDHA genes supports the evolutionary relatedness of the 2 isozymes. Edwards et al. (1989) reported mapping of LDHC to 11p15.5-p15.3 by combination of somatic cell hybrid studies and in situ hybridization.

Tags: 11p15.1