NADH-UBIQUINONE OXIDOREDUCTASE 1 BETA SUBCOMPLEX, 2; NDUFB2

HGNC Approved Gene Symbol: NDUFB2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,696,707-140,706,642 (from NCBI)

▼ Description
The multisubunit NADH:ubiquinone oxidoreductase (complex I) is the first enzyme complex in the electron transport chain of mitochondria. NDUFB2 is a nuclear encoded subunit located in the hydrophobic protein fraction of complex I (Loeffen et al., 1998).

▼ Cloning and Expression
By EST database searching and PCR, Loeffen et al. (1998) isolated human cDNAs encoding NDUFB2 and 7 other complex I subunits. The predicted 105-amino acid human protein is 84% identical to Aggg, its bovine homolog. Hydropathy analysis revealed that NDUFB2 and 4 other subunits had an overall hydrophilic pattern, even though they were found within the hydrophobic protein fraction of complex I.