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RAS AND EF-HAND DOMAINS-CONTAINING PROTEIN; RASEF

RAS AND EF-HAND DOMAINS-CONTAINING PROTEIN; RASEF

HGNC Approved Gene Symbol: RASEFCytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:82,979,588-83,063,171 (from NCBI)▼ Cloning and ExpressionBy sea...

HGNC Approved Gene Symbol: RASEF

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:82,979,588-83,063,171 (from NCBI)

▼ Cloning and Expression
By searching for genes in a region of chromosome 9q commonly deleted in acute myeloid leukemia (AML; 601626), followed by PCR of CD34 (142230)-positive bone marrow cells, Sweetser et al. (2005) cloned RASEF. The deduced 844-amino acid protein contains a domain found in RAS (HRAS; 190020) family GTP-binding proteins.

▼ Gene Structure
Sweetser et al. (2005) determined that the RASEF gene contains 17 exons.

▼ Mapping
By genomic sequence analysis, Sweetser et al. (2005) mapped the RASEF gene to chromosome 9q21.32

Tags: 9q21.32