KRR1 SMALL SUBUNITPROCESSOME COMPONENT HOMOLOG; KRR1

Alternative titles; symbols

• KRR1, YEAST, HOMOLOG OF

HGNC Approved Gene Symbol: KRR1

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:75,490,862-75,511,608 (from NCBI)

▼ Cloning and Expression
In yeast, Krr1 is a component of a ribonucleoprotein required for biogenesis of the 18S rRNA. By database analysis, Bernstein et al. (2004) identified human KRR1.

By searching a human database for sequences similar to Drosophila dribble (dbe), Chan et al. (2001) identified the human ortholog, KRR1. Dribble and KRR1 share highest similarity in their ribonucleoprotein K (HNRNPK; 600712) homology (KH) domains. In Drosophila, dribble localized to the nucleus, and in some cell types to a subregion of the nucleolus.

▼ Gene Function
Chan et al. (2001) found that dribble was required for survival of dividing cells during Drosophila development. Dribble mutants showed a defect in rRNA processing and accumulated abnormal rRNA precursors.

▼ Mapping
Hartz (2009) mapped the KRR1 gene to chromosome 12q21.2 based on an alignment of the KRR1 sequence (GenBank U00943) with the genomic sequence (build 36.1).