Alternative titles; symbolsKRR1, YEAST, HOMOLOG OFHGNC Approved Gene Symbol: KRR1Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:75,490,862-75...
Alternative titles; symbols
HGNC Approved Gene Symbol: KRR1
Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:75,490,862-75,511,608 (from NCBI)
▼ Cloning and Expression
In yeast, Krr1 is a component of a ribonucleoprotein required for biogenesis of the 18S rRNA. By database analysis, Bernstein et al. (2004) identified human KRR1.
By searching a human database for sequences similar to Drosophila dribble (dbe), Chan et al. (2001) identified the human ortholog, KRR1. Dribble and KRR1 share highest similarity in their ribonucleoprotein K (HNRNPK; 600712) homology (KH) domains. In Drosophila, dribble localized to the nucleus, and in some cell types to a subregion of the nucleolus.
▼ Gene Function
Chan et al. (2001) found that dribble was required for survival of dividing cells during Drosophila development. Dribble mutants showed a defect in rRNA processing and accumulated abnormal rRNA precursors.
Hartz (2009) mapped the KRR1 gene to chromosome 12q21.2 based on an alignment of the KRR1 sequence (GenBank U00943) with the genomic sequence (build 36.1).