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COILED-COIL DOMAIN-CONTAINING PROTEIN 86; CCDC86

COILED-COIL DOMAIN-CONTAINING PROTEIN 86; CCDC86

Alternative titles; symbolsCYTOKINE-INDUCED PROTEIN WITH COILED-COIL DOMAIN; CYCLONHGNC Approved Gene Symbol: CCDC86Cytogenetic location: 11q12.2 Genomic coo...

Alternative titles; symbols

  • CYTOKINE-INDUCED PROTEIN WITH COILED-COIL DOMAIN; CYCLON

HGNC Approved Gene Symbol: CCDC86

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,842,112-60,851,080 (from NCBI)

▼ Cloning and Expression
In a search for transcripts upregulated by interleukin-3 (IL3; 147740) and detected on expression arrays, Hoshino and Fujii (2007) identified the CCDC86 gene, which they named cyclon (cytokine-induced protein with coiled-coil domain). CCDC86 encodes a deduced 360-amino acid protein with a coiled-coil domain in the C terminus and repetitive sequences, which the authors referred to as SP repeats, near the N terminus. The SP repeats are shorter in the human and rat orthologs than in mice. The protein has 3 potential bipartite nuclear localization signals. Its promoter has redundant IL3-responsive elements, which were confirmed experimentally.

Hoshino and Fujii (2007) detected mouse Ccdc86 mRNA expression as early as 30 minutes after induction of IL3, indicating that it is an immediate early gene. Northern blot analysis of mouse tissues detected expression predominantly in testis but also in heart, liver, and kidney. Ccdc86 expression was also detected in activated mouse peripheral CD4+ and CD8+ T cells. Immunoblots of HA-tagged human or mouse CCDC86 detected the protein in nuclear extracts. The nuclear localization was confirmed by microscopy, and the protein was shown to be phosphorylated. Hoshino and Fujii (2007) speculated that CCDC86 may play a role in the regulation of immune homeostasis.

▼ Gene Structure
Hoshino and Fujii (2007) determined that both the human and mouse CCDC86 genes contain 4 exons.

▼ Mapping
Hoshino and Fujii (2007) stated that the human and mouse CCDC86 genes map to chromosome 11q12 and chromosome 19B, respectively.

Tags: 11q12.2