MICRO RNA 139; MIR139

Alternative titles; symbols

• miRNA139
• MIR139-5p

Other entities represented in this entry:

MICRO RNA 139-3p, INCLUDED; MIR139-3p, INCLUDED

HGNC Approved Gene Symbol: MIR139

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,615,062-72,615,129 (from NCBI)

▼ Description
Micro RNAs (miRNAs), such as MIR139, are small noncoding RNAs that bind target mRNAs in a sequence-specific manner and mediate their posttranscriptional repression through translational inhibition or mRNA degradation. The MIR139 stem-loop structure can generate 2 mature miRNAs, MIR139-5p and MIR139-3p, from its 5-prime and 3-prime ends, respectively (Shen et al., 2012).

▼ Gene Function
Shen et al. (2012) stated that MIR139 expression is downregulated in parathyroid cancer and squamous cell carcinoma. By expression profiling, they found that MIR139, predominantly MIR139-5p, was also downregulated in human colorectal carcinomas. Low expression of MIR139-5p was associated with tumor staging, lymph node involvement, vascular invasion, and metastasis. Reexpression of MIR139 in the HCT116 and LOVO colorectal carcinoma cell lines did not inhibit cell growth, but it suppressed cell migration in vitro and inhibited metastases following inoculation into nude mice. Expression of MIR139 correlated inversely with expression of a putative MIR139 target, IGF1R (147370). Increased IGF1R expression in HCT116 and LOVO cells induced expression of matrix metalloprotease-2 (MMP2; 120360) via MEK (see 176872)/ERK (see 601795)/p65 (RELA; 164014) signaling.

▼ Mapping
By genomic sequence analysis, Shen et al. (2012) mapped the MIR139 gene to chromosome 11q13.4.