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OTU DOMAIN-CONTAINING PROTEIN 1; OTUD1

OTU DOMAIN-CONTAINING PROTEIN 1; OTUD1

Alternative titles; symbolsDUBA7HGNC Approved Gene Symbol: OTUD1Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:23,439,074-23,442,376 (from NC...

Alternative titles; symbols

  • DUBA7

HGNC Approved Gene Symbol: OTUD1

Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:23,439,074-23,442,376 (from NCBI)

▼ Description
Deubiquitinating enzymes (DUBs; see 603478) are proteases that specifically cleave ubiquitin (191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.

▼ Cloning and Expression
Kayagaki et al. (2007) identified ovarian tumor domain (OTU)-containing protein 1 (OTUD1) in a small interfering RNA (siRNA)-based screen for OTU deubiquitinating enzyme (DUB) family members. The 3,389-basepair mRNA contains an open reading frame (ORF) predicting a 638-amino acid protein. OTUD1 contains, in addition to an OTU domain, a ubiquitin interaction motif (UIM) at the carboxy terminus.

▼ Mapping
The OTUD1 gene maps to chromosome 10p12.2 (Kayagaki et al., 2007).

▼ Animal Model
In a study of susceptibility to C. albicans infection, Chen et al. (2021) found that Otud1 knockout mice had reduced production of cytokines, which attenuated the ability to stop infection. Overexpression of OTUD1 in HEK293T cells resulted in reduced CARD9 (607212) ubiquitination. Coprecipitation studies confirmed an interaction between CARD9 and OTUD1.

Tags: 10p12.2