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F-BOX AND WD40 DOMAIN PROTEIN 12; FBXW12

F-BOX AND WD40 DOMAIN PROTEIN 12; FBXW12

Alternative titles; symbolsFBW12FBXO35FBXO12HGNC Approved Gene Symbol: FBXW12Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,372,218-48,394,...

Alternative titles; symbols

  • FBW12
  • FBXO35
  • FBXO12

HGNC Approved Gene Symbol: FBXW12

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,372,218-48,394,829 (from NCBI)

▼ Description
Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (601434), cullin (see CUL1; 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).

▼ Cloning and Expression
By large-scale sequence analysis of a fetal brain cDNA library, Zeng et al. (2004) cloned FBXW12, which they designated FBXO35. The deduced 464-amino acid protein has a calculated molecular mass of 53.1 kD. FBXW12 contains a conserved F-box domain. RT-PCR detected highest expression in placenta and brain and intermediate expression in all other tissues tested except prostate, testis, and peripheral blood leukocytes, which showed no expression.

Jin et al. (2004) reported that the FBXW12 protein contains an F box in its N-terminal half, followed by 4 WD40 repeats.

▼ Gene Structure
Zeng et al. (2004) determined that the FBXW12 gene contains 11 exons and spans about 22 kb.

▼ Mapping
By genomic sequence analysis, Zeng et al. (2004) mapped the FBXW12 gene to chromosome 3p21.

Tags: 3p21.31