HGNC Approved Gene Symbol: GPR176Cytogenetic location: 15q14-q15.1 Genomic coordinates (GRCh38): 15:39,795,048-39,920,938 (from NCBI)▼ DescriptionMembers of ...
HGNC Approved Gene Symbol: GPR176
Cytogenetic location: 15q14-q15.1 Genomic coordinates (GRCh38): 15:39,795,048-39,920,938 (from NCBI)
Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995).
▼ Cloning and Expression
By screening a fetal brain cDNA library with rat Gpr176, Hata et al. (1995) cloned full-length human GPR176, which they called HB954. The deduced protein contains 515 amino acids and has a calculated molecular mass of 57.0 kD. GPR176 has 4 N-glycosylation sites near its N terminus, 7 transmembrane domains, and a large C-terminal cytosolic domain. Northern blot analysis of rat tissues showed low expression in brain and spleen, trace expression in kidney, and no expression in heart or testis.
Gross (2017) mapped the GPR176 gene to chromosome 15q14-q15.1 based on an alignment of the GPR176 sequence (GenBank BC067106) with the genomic sequence (GRCh38).