Alternative titles; symbolsPCDH-GAMMA-A6HGNC Approved Gene Symbol: PCDHGA6Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,373,890-141,512,97...
Alternative titles; symbols
HGNC Approved Gene Symbol: PCDHGA6
Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,373,890-141,512,974 (from NCBI)
Cadherins are calcium-dependent cell-cell adhesion molecules, and protocadherins constitute a subfamily of nonclassic cadherins. PCDHGA6 is 1 of 22 tandemly arranged genes within the PCDHG gene cluster (604968) on chromosome 5q31. The 22 PCDHG genes function as 'variable' exons that are individually spliced to a downstream constant region to form distinct PCDHG transcripts. The variable PCDHG exons encode the extracellular and transmembrane domains of the protocadherin protein, and the common region encodes the intracellular domain (Wu et al., 2001). For further information on the PCDHG genes, see 604968.
▼ Cloning and Expression
By PCR of a brain cDNA library, Wu and Maniatis (1999) cloned full-length PCDHGA6.
By genomic sequence analysis, Wu et al. (2001) mapped the PCDHGA6 gene to chromosome 5q31, between the PCDHGB3 gene (606301) and the PCDHGA7 gene (606294). They localized the mouse PCDHG genes to chromosome 18c.