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GROWTH ARREST-SPECIFIC 7; GAS7

GROWTH ARREST-SPECIFIC 7; GAS7

HGNC Approved Gene Symbol: GAS7Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,910,605-10,198,605 (from NCBI)▼ Cloning and ExpressionGrowth ...

HGNC Approved Gene Symbol: GAS7

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,910,605-10,198,605 (from NCBI)

▼ Cloning and Expression
Growth arrest-specific (GAS) genes are expressed preferentially in cells that enter a quiescent state. Ju et al. (1998) described the isolation and characterization of a GAS gene (GAS7) that is expressed primarily in vivo in terminally differentiated brain cells and particularly prominently in mature cerebellar Purkinje neurons. The gene had originally been identified in serum-starved murine fibroblasts. GAS7 transcripts encode a 48-kD protein containing a structural domain that resembles sequences of OCT2 (602608), a POU transcription factor implicated in neuronal development, and synapsins, e.g., synapsin I (SYN1; 313440), which have a role in modulating neurotransmitter release.

GAS7/MLL Fusion Gene

Leukemias with myeloid/lymphoid (MLL;159555) gene translocations are a complication of primary cancer treatment with DNA topoisomerase II inhibitors. Megonigal et al. (2000) tracked a leukemic clone with an MLL gene translocation during neuroblastoma therapy in a child who had developed acute myeloid leukemia. The karyotype of the leukemic clone showed del(11)(q23). They used panhandle PCR-based methods to isolate the breakpoint junction involving MLL and an unknown partner gene. The karyotypic del(11)(q23) was a cryptic t(11;17). GAS7 at 17p13 was the partner gene of MLL. Two different MLL-GAS7 fusion transcripts were expressed. The translocation was already detectable by 1.5 months after the start of neuroblastoma treatment. The translocation was not detectable in the marrow at neuroblastoma diagnosis or in peripheral blood lymphocyte DNAs of 6 normal subjects.

▼ Gene Function
Using in situ hybridization and immunocytochemical analysis, Ju et al. (1998) showed that inhibition of production of GAS7 in terminally differentiating cultures of embryonic murine cerebellum impedes neurite outgrowth from maturing Purkinje cells. Conversely, GAS7 overexpression in undifferentiated neuroblastoma cell cultures dramatically promotes neurite-like outgrowth. Collectively, the results provided evidence for an association between expression of GAS7 and neuronal development.

▼ Mapping
By analysis of cell hybrid DNAs prepared from a panel of 21 Chinese hamster/mouse hybrid cell lines, Ju et al. (1998) mapped the mouse Gas7 gene to chromosome 11. They reported that a human DNA fragment (GenBank G13706) having 85% sequence identity with Gas7 mapped to 17p, which is largely syngeneic with mouse chromosome 11 (Kurtz and Zimmer, 1995).

Tags: 17p13.1