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HORMONALLY UPREGULATED NEU-ASSOCIATED KINASE; HUNK

HORMONALLY UPREGULATED NEU-ASSOCIATED KINASE; HUNK

HGNC Approved Gene Symbol: HUNKCytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:31,873,019-32,004,063 (from NCBI)▼ Cloning and ExpressionGardn...

HGNC Approved Gene Symbol: HUNK

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:31,873,019-32,004,063 (from NCBI)

▼ Cloning and Expression
Gardner et al. (2000) cloned a full-length mouse cDNA encoding Hunk. The deduced 714-amino acid serine/threonine kinase is 92% identical to the human protein. Immunoblot analysis detected an 80-kD protein expressing phosphotransferase activity. In situ hybridization analysis showed developmentally regulated and tissue-specific expression in fetal mice; expression was more restricted in adult mice.

▼ Gene Function
Wertheim et al. (2009) found that Myc (190080)-induced mouse tumors showed a higher metastatic potential when they also expressed Hunk, and that migration and invasion of Hunk-expressing tumors depended upon Hunk kinase activity. Human breast cancers with gene expression profiles similar to those of mouse Hunk-wildtype tumors showed a higher incidence of metastasis and recurrence, as well as poorer prognosis, compared with human tumors with expression profiles similar to those of mouse Hunk-deficient tumors.

▼ Mapping
Hartz (2011) mapped the HUNK gene to chromosome 21q22.11 based on an alignment of the HUNK sequence (GenBank AJ271722) with the genomic sequence (GRCh37).

By interspecific backcross analysis, Gardner et al. (2000) mapped the mouse Hunk gene to chromosome 16, in a region showing homology of synteny to human chromosome 21q22.

▼ Animal Model
Wertheim et al. (2009) found that Hunk deletion in mice did not alter viability, fertility, longevity, or propensity to develop tumors. They concluded that Hunk is dispensable for murine development.

Tags: 21q22.11