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SOLUTE CARRIER FAMILY 25, MEMBER 52; SLC25A52

SOLUTE CARRIER FAMILY 25, MEMBER 52; SLC25A52

Alternative titles; symbolsMITOCHONDRIAL CARRIER TRIPLE REPEAT 2; MCART2HGNC Approved Gene Symbol: SLC25A52Cytogenetic location: 18q12.1 Genomic coordinates ...

Alternative titles; symbols

  • MITOCHONDRIAL CARRIER TRIPLE REPEAT 2; MCART2

HGNC Approved Gene Symbol: SLC25A52

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:31,759,583-31,760,879 (from NCBI)

▼ Description
SLC25A52 is a member of the large SLC25 family of transporters that localize predominantly to the inner mitochondrial membrane. Members of this family have 3 tandem repeats of an approximately 100-amino acid domain, each repeat of which has 2 membrane-spanning alpha helices and a signature sequence motif, and the N and C termini of the transporter face the cytosol. The 6 transmembrane domains of SLC25 family members line a funnel-shaped cavity that alternately opens to the cytosol or mitochondrial matrix in a ligand- and conformation-dependent manner (review by Palmieri, 2013).

▼ Mapping
The SLC25A52 gene maps to chromosome 18q12.1 (Palmieri, 2013).

Tags: 18q12.1