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Alternative titles; symbols2-PRIME,5-PRIME-OLIGOADENYLATE SYNTHETASE, 100-KDp100HGNC Approved Gene Symbol: OAS3Cytogenetic location: 12q24.13 Genomic coordin...

Alternative titles; symbols

  • p100

HGNC Approved Gene Symbol: OAS3

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,938,462-112,973,250 (from NCBI)

▼ Description
The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS3, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As) (Hovnanian et al., 1998). For further information on OASs, see OAS1 (164350).

▼ Cloning and Expression
Hovanessian et al. (1987) found that interferon-treated human cells contain several OASs corresponding to proteins of 40 (OAS1), 46 (OAS1), 69 (OAS2; 603350), and 100 (OAS3) kD. Hovnanian et al. (1998) reported that the predicted OAS3, or p100, protein contains 3 adjacent OAS1-like domains. The domains share 44 to 60% protein sequence similarity with each other and 42 to 60% sequence identity with the conserved domain of OAS1. The authors noted that OAS1, OAS2, and OAS3 contain 1, 2, and 3 conserved OAS domains or units, respectively. Northern blot analysis revealed that OAS3 is expressed as a 7-kb interferon-induced mRNA in HeLa cells.

▼ Gene Function
Using a human lung cell line, Lin et al. (2009) showed that RNASEL (180435) played an antiviral role against Dengue virus (see 614371). Of the 10 OAS isoforms generated by alternative splicing of the 4 human OAS genes, only the p42 and p46 isoforms of OAS1 and the p100 isoform of OAS3 blocked Dengue virus replication by inducing RNASEL activity in infected cells.

▼ Mapping
By fluorescence in situ hybridization and by inclusion within mapped clones, Hovnanian et al. (1998) determined that the OAS1, OAS2, and OAS3 genes are clustered with a 130-kb region on chromosome 12q24.2.

Tags: 12q24.13