DACHSOUS CADHERIN-RELATED 2; DCHS2

Alternative titles; symbols

• DACHSOUS, DROSOPHILA, HOMOLOG OF, 2

Other entities represented in this entry:

• CADHERIN J, INCLUDED; CDHJ, INCLUDED
• PROTOCADHERIN J, INCLUDED; PCDHJ, INCLUDED

HGNC Approved Gene Symbol: DCHS2

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:154,231,741-154,491,798 (from NCBI)

▼ Cloning and Expression
By searching databases using a cadherin (see 192090) motif, Hoeng et al. (2004) identified CDHJ and PCDHJ. CDHJ has 25 exons and encodes a deduced 2,916-amino acid protein containing a long N-terminal ectodomain with numerous individual cadherin domains, followed by a transmembrane domain and a C-terminal domain. PCDHJ has 2 exons and encodes a deduced 702-amino acid protein with 5 cadherin domains. PCR analysis detected 2 CDHJ variants in cerebral cortex and testis only. Hartz (2008) determined that the CDHJ and PCDHJ transcripts use nonoverlapping 5-prime and 3-prime exons of the full-length DCHS2 gene, respectively.

▼ Mapping
By genomic sequence analysis, Hoeng et al. (2004) mapped the DCHS2 gene to chromosome 4q31.3. They mapped the mouse Dchs2 gene to a syntenic region of mouse chromosome 3.