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TRANSCRIPTION FACTOR-LIKE 5; TCFL5

TRANSCRIPTION FACTOR-LIKE 5; TCFL5

HGNC Approved Gene Symbol: TCFL5Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,841,004-62,861,821 (from NCBI)▼ Cloning and ExpressionTran...

HGNC Approved Gene Symbol: TCFL5

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,841,004-62,861,821 (from NCBI)

▼ Cloning and Expression
Transcription factors containing basic helix-loop-helix (bHLH) motifs play important roles in the regulation of neurogenesis, myogenesis, cardiogenesis, cell proliferation, and differentiation. By differential display analysis of PCR products from mRNAs isolated from 9 different human tissues, Maruyama et al. (1998) identified a testis-specific cDNA, which they designated transcription factor-like-5 (TCFL5), encoding a 452-amino acid protein that contains a bHLH motif. Immunohistochemical staining located the gene product exclusively in cell nuclei of primary spermatocytes at the pachytene stage. The authors concluded that TCFL5 may function as a transcription factor in spermatogenesis through binding to a specific DNA sequence.

▼ Gene Structure
Maruyama et al. (1998) determined that the TCFL5 gene contains 6 exons and spans approximately 24 kb of genomic DNA.

▼ Mapping
By fluorescence in situ hybridization, Maruyama et al. (1998) mapped the TCFL5 gene to chromosome 20q13.3-qter.

Tags: 20q13.33