Alternative titles; symbolsmiRNA433MIRN433HGNC Approved Gene Symbol: MIR433Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:100,881,885-100,881...
Alternative titles; symbols
HGNC Approved Gene Symbol: MIR433
Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:100,881,885-100,881,977 (from NCBI)
MicroRNAs (miRNAs), such as MIRN433, are noncoding RNA molecules of about 22 nucleotides that play important roles in gene regulation (Altuvia et al., 2005).
▼ Cloning and Expression
By database and sequence analyses, Altuvia et al. (2005) identified MIRN433 within an miRNA cluster on chromosome 14, and they cloned MIRN433 from human pituitary gland. The mature MIRN433 sequence is AUCAUGAUGGGCUCCUCGGUGU.
▼ Gene Function
Wang et al. (2008) identified a single-nucleotide polymorphism (SNP) in the gene encoding fibroblast growth factor-20 (FGF20; 605558) that increases susceptibility to Parkinson disease (PD; 168600) by disrupting MIRN433 binding. In several functional assays, Wang et al. (2008) showed that the risk allele of rs12720208 (605558.0001) disrupts a binding site for MIRN433, increasing translation of FGF20 in vitro and in vivo. In a cell-based system and in PD brains, this increase in translation of FGF20 correlated with increased expression of alpha-synuclein (SNCA; 163890), which had been shown to cause PD through both overexpression and point mutations. Wang et al. (2008) suggested a novel mechanism of action for PD risk in which the modulation of a susceptibility gene's translation by common variations interferes with the regulation of mechanisms of microRNA. They proposed that this may be a common mechanism of genetic modulation of individual susceptibility to complex disease.
By genomic sequence analysis, Altuvia et al. (2005) mapped the MIRN433 gene within an miRNA cluster on chromosome 14 that includes MIRN127 (611709), MIRN136 (611710), and MIRN431 (611709).