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Alternative titles; symbolsPROTEASOMAL SUBUNIT C5; HC5PROTEASOME SUBUNIT BETA-6HGNC Approved Gene Symbol: PSMB1Cytogenetic location: 6q27 Genomic coordinates...

Alternative titles; symbols


HGNC Approved Gene Symbol: PSMB1

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:170,535,119-170,553,306 (from NCBI)

▼ Cloning and Expression
Tamura et al. (1994) isolated 2 human proteasome genes encoding the alpha-type HC3 (PSMA2; 176842) and the beta-type HC5 subunits. Analysis of their promoter sequences revealed the absence of TATA and CAAT elements and the existence of 2 or 3 GC boxes that function coordinately as promoters of the 2 genes. Differences in the exon/intron organizations of these genes, however, suggested that they diverged at an early stage of evolution.

▼ Mapping
Trachtulec et al. (1997) mapped the human PSMB1 gene to a region of chromosome 6q27 syntenic with the proximal part of mouse chromosome 17, where the mouse homolog maps. In both human and mouse PSMB1 is tightly linked to the TATA-binding protein gene (TBP; 600075). The 2 genes are transcribed in the opposite orientation in both species.

▼ Gene Family
The TATA-binding protein (TBP) is a factor required for the transcription of all classes of eukaryotic genes. The human TBP and mouse Tbp are single-copy genes; in Drosophila TATA-binding protein genes, the housekeeping Tbp and the developmentally regulated Trf, map to opposite arms of the second chromosome. Trachtulec et al. (1997) demonstrated in the mouse that the Tbp gene resides next to the proteasomal subunit C5-encoding gene (Psmb1). The genes are located on mouse chromosome 17 in the t complex within the 'Hybrid sterility 1' (Hst1) region. They also demonstrated that the homologous human genes, TBP and PSMB1, are tightly linked on chromosome 6q27 in a region syntenic with the proximal part of mouse chromosome 17. The TATA-binding protein and proteasomal subunit C5 genes are also linked on chromosome III of C. elegans, and together they are linked to other genes whose homologs map to human chromosome 6 and mouse chromosome 17. In Drosophila, the 2 housekeeping TATA-binding protein genes map close to 2 other genes with homologs in the mammalian major histocompatibility complex. Thus, Trachtulec et al. (1997) concluded that there exists conserved synteny of unrelated genes between mammals and invertebrates.

See PSMB2 (602175) for further discussion of this gene family.

▼ History
Okumura et al. (1995) mapped the PSMB1 gene to chromosome 7p13-p12 by fluorescence in situ hybridization.

Tags: 6q27