Alternative titles; symbolsSTAT-INDUCED STAT INHIBITOR 4; SSI4; STAI4CYTOKINE-INDUCIBLE SH2 PROTEIN 4; CIS4SUPPRESSOR OF CYTOKINE SIGNALING 4, FORMERLY; SOCS4, F...
Alternative titles; symbols
HGNC Approved Gene Symbol: SOCS6
Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:70,289,044-70,330,198 (from NCBI)
▼ Cloning and Expression
Masuhara et al. (1997) identified multiple members of the cytokine-inducible SH2 protein, or CIS, family. See 603597. CIS family members have an SH2 domain, which has 23 to 58% identity among members. There is also a relatively conserved C-terminal region, which Masuhara et al. (1997) termed the CIS homology domain, or CH domain. CIS4 has a very long N-terminal region of about 380 amino acids; the N-terminal region of other CIF family members is 40 to 80 amino acids in length. CIS4 expression was found to be high in factor-independent chronic myelogenous leukemia (CML; 608232) and human erythroleukemia (HEL) cell lines but low in B cell lines. CIS4 was not found to interact with any tyrosine kinases. Expression of CIS4 was induced by GM-CSF and EPO (133170) in certain cell lines.
Gross (2015) mapped the SOCS6 gene to chromosome 18q22.2 based on an alignment of the SOCS6 sequence (GenBank AB006968) with the genomic sequence (GRCh38).