HGNC Approved Gene Symbol: MRPS6Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:34,073,577-34,143,029 (from NCBI)▼ DescriptionMitochondria ha...
HGNC Approved Gene Symbol: MRPS6
Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:34,073,577-34,143,029 (from NCBI)
Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation. MRPS6 is 1 of more than 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome (Kenmochi et al., 2001).
▼ Cloning and Expression
By proteolytic digestion of whole bovine 28S subunits, followed by peptide analysis and EST database analysis, Koc et al. (2001) identified full-length human MRPS6. The deduced 125-amino acid MRPS6 protein has a calculated molecular mass of 14.2 kD. Koc et al. (2001) identified MRPS6 orthologs in mouse, Drosophila, C. elegans, yeast, and E. coli. Highest conservation is in the N-terminal end and central region of MRPS6 orthologs. Mouse and human MRPS6 share 84.8% amino acid identity.
By radiation hybrid analysis and analysis of an integrated BAC-STS map, Kenmochi et al. (2001) mapped the MRPS6 gene to chromosome 21q21.3-q22.1.