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Alternative titles; symbolsCINNCytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:163,600,000-169,200,000▼ Clinical FeaturesKnaapila et al. (2007) ...

Alternative titles; symbols

  • CINN

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:163,600,000-169,200,000

▼ Clinical Features
Knaapila et al. (2007) evaluated the identification, intensity, and pleasantness of 12 different odors in 146 adult Finnish individuals from 26 families who were participating in a migraine study; 84% of subjects had migraine with or without aura, and 16% were healthy relatives. The individuals were further classified into nonsmokers (58%) and smokers (42%). All subjects underwent the brief smell identification test (B-SIT), also known as the cross-cultural smell identification test (CC-SIT) (Doty et al., 1996), which consists of microencapsulated odors of cinnamon, turpentine, lemon, smoke, chocolate, rose, paint thinner, banana, pineapple, gasoline, soap, and onion on a scratch-and-sniff sheet. Of note, there was no difference in identification, pleasantness, or intensity scores between individuals with migraine and healthy controls, except for gasoline, which was more intense for migraineurs.

▼ Inheritance
By genomewide linkage analysis for intensity and pleasantness of 5 odors, cinnamon, turpentine, lemon, rose, and banana, in 146 adult Finnish individuals, Knaapila et al. (2007) found that the pleasantness of cinnamon had the highest heritability (65%). Knaapila et al. (2007) noted the limitations of their study, including complex environmental influences, the subjective nature of the test, and the inability of the test to detect minor variations in individuals with normal olfactory function. There was also no significant linkage for odor identification, suggesting that it is a complex process involving several different genes and multiple cognitive processing signals.

▼ Mapping
Knaapila et al. (2007) found evidence for suggestive linkage between pleasantness of cinnamon odor and marker AFM295YE5 on chromosome 4q32.3 (multipoint lod score of 3.01). The authors also found lesser evidence of linkage for intensity of paint thinner odor on chromosome 2p14 (multipoint lod score of 2.55).

Tags: 4q32.3