F-BOX AND LEUCINE-RICH REPEAT PROTEIN 16; FBXL16

Alternative titles; symbols

• FBL16
• CHROMOSOME 16 OPEN READING FRAME 22; C16ORF22

HGNC Approved Gene Symbol: FBXL16

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:692,499-707,852 (from NCBI)

▼ Description
Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (601434), cullin (see CUL1; 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).

▼ Cloning and Expression
Jin et al. (2004) reported that the human FBXL16 protein contains an F box in its N-terminal half, followed by a spacer, 8 tandemly arrayed leucine-rich repeats, another spacer, and a C-terminal leucine-rich repeat.

▼ Mapping
By sequence analysis, Daniels et al. (2001) mapped the FBXL16 gene, which they called C16ORF22, to a gene-rich region of chromosome 16p13.3.

Jin et al. (2004) stated that the mouse Fbxl16 gene maps to chromosome 17A3.3.