Alternative titles; symbolsATP5JGHGNC Approved Gene Symbol: ATP5MGCytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,401,605-118,409,846 (fro...
Alternative titles; symbols
HGNC Approved Gene Symbol: ATP5MG
Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,401,605-118,409,846 (from NCBI)
ATP5L is a subunit of the F0 ATPase complex, which is involved in generation of ATP (Dahiya et al., 2017).
▼ Cloning and Expression
By sequencing clones obtained from a CD34 (142230)-positive hematopoietic stem/progenitor cell cDNA library, Zhang et al. (2000) cloned ATP5L, which they designated F1F0-ATPase synthase g. The deduced protein contains 103 amino acids. ATP5L was highly expressed in all 5 human hematopoietic cell lines examined. An ortholog of ATP5L was detected in nonprimate mammals, C. elegans, and Drosophila, but not in yeast or Arabidopsis.
▼ Gene Function
Dahiya et al. (2017) identified 2 seed sequences for the microRNA MIR570 (614538) in the 3-prime UTR of ATP5L transcript. Overexpression of MIR570 in human platelets downregulated ATP5L mRNA and had a modest effect in reducing platelet ATP content. Reporter gene assays confirmed that MIR570 negatively regulates ATP5L expression via the 3-prime UTR of ATP5L.
▼ Gene Structure
Zhang et al. (2000) determined that the ATP5L gene contains at least 3 exons.
Zhang et al. (2000) stated that the ATP5L gene maps to chromosome 11q22.3.